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The occurrence of ferroptosis in mature erythrocytes has not been confirmed and it seems quite challenging, since ferroptosis studies suffer from the lack of well-established markers and evaluation of this cell death requires a complex approach with identification of typical cellular and subcellular morphological alterations, genetic hallmarks, biochemical changes, expression of certain ferroptosis-related proteins, etc

The real magic happens at the cellular level

However, studies confirm that glutathione is the most s ignificant antioxidant in the human body due to its regenerative power

Forced BNIP-3 expression by plasmid transfection results in mitochondrial Endo G release and nuclear translocation

Franco R, Schoneveld OJ, Pappa A, Panayiotidis MI